Tag: disc

Disc Medicine Initiates BEACON, a Phase 2 Clinical Study of Bitopertin in Patients with Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP)
August 10, 2022

Disc Medicine Initiates BEACON, a Phase 2 Clinical Study of Bitopertin in Patients with Erythropoietic Protoporphyria (EPP) and X-linked Protoporphyria (XLP)

BEACON study will evaluate bitopertin as a potential disease-modifying treatment for patients with Erythropoietic Protoporphyria (EPP) or X-linked Protoporphyria (XLP) Key assessments include changes in protoporphyrin IX levels, safety, tolerability and measures of photosensitivity; preliminary data expected by 1H 2023 WATERTOWN, Mass., Aug. 10, 2022 /PRNewswire/ — Disc Medicine, a clinical-stage biotechnology company dedicated to the discovery and development of …
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Forgoing animal experiments: a case study in intervertebral disc regenerative medicine | Centre for Bioengineering and Biotechnology
July 7, 2022

Forgoing animal experiments: a case study in intervertebral disc regenerative medicine | Centre for Bioengineering and Biotechnology

Abstracts The intervertebral disc (IVD), a fibro-cartilaginous structure acting as a natural shock absorber, contains an outer network of collagen fibers (annulus fibrosus) surrounding a central gelatinous (nucleus pulposus). Low back pain, affecting over 80% of adults during their lifetime and resulting in considerable disability and socioeconomic consequences, has been associated with IVD degeneration. On one hand, preclinical animal models …
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