Tag: BMC

Recommendations for robust and reproducible preclinical research in personalised medicine | BMC Medicine

Clinically relevant translational research Despite recent developments of sophisticated and novel methods in preclinical research, there is still a deficiency of models that can reliably replicate patient groups sufficiently to enable benefits from PM to be realised. Only a small proportion of preclinical research performed prior to clinical trials translates into clinical benefit in humans , for instance in Alzheimer’s …

Ethical and regulatory issues of stem cell-derived 3-dimensional organoid and tissue therapy for personalised regenerative medicine | BMC Medicine

Mansour AA, Gonçalves JT, Bloyd CW, Li H, Fernandes S, Quang D, et al. An in vivo model of functional and vascularized human brain organoids. Nat Biotechnol. 2018;36(5):432–41. Article  CAS  Google Scholar  https://www.tmd.ac.jp/press-release/20220707-1/. 2022. Read moreVeterinary Medicine Market Latest Innovation, Upcoming Trends Analysis, Top Companies, Demand by Regions and Forecast by 2029 – Indian Defence NewsNational Acadamy of Sciences. Guidelines …

Obese visceral fat tissue inflammation: from protective to detrimental? | BMC Medicine

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2018;9:7204. Article  Google Scholar  Medzhitov R. The spectrum of inflammatory responses. Science. 2021;374:1070. Read moreGlobal Veterinary Medicine Market to Witness Exponential Growth by 2030 – PRIZM NewsArticle  CAS  Google Scholar  Psaila AM, Vohralik EJ, Quinlan KGR. Shades of …

Genomic epidemiology of Escherichia coli: antimicrobial resistance through a One Health lens in sympatric humans, livestock and peri-domestic wildlife in Nairobi, Kenya | BMC Medicine

Murray CJL, Ikuta KS, Sharara F, Swechinsky L, Robles Aguilar G, Gray A, et al. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. lancet Tang KL, Caffrey NP, Nobrega DB, Cork SC, Ronksley PE, Barkema HW, et al. Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human …

Plant-based dietary patterns defined by a priori indices and colorectal cancer risk by sex and race/ethnicity: the Multiethnic Cohort Study | BMC Medicine

study population The MEC is a population-based, prospective cohort study designed to investigate lifestyle and genetic factors related to cancer and other chronic diseases . Participants were identified from the sources including driver’s license records, voter registration lists, and Health Care Financing Administration data files. They were recruited by mailing an invitation letter and questionnaire . More than 215,000 adults …

Intestinal gluconeogenesis is downregulated in pediatric patients with celiac disease | BMC Medicine

The present study shows that children with untreated CD have lower expression of genes involved in IGN in duodenal biopsies compared with children with a normal intestinal mucosa. Decreased expression is correlated to a higher Marsh score and, to a lesser degree, tTG antibody levels. These results suggest that CD patients could have an impaired function of IGN, either as …

Added flavors: potential contributors to body weight gain and obesity? | BMC Medicine

European Food Safety Authority. Food additives. https://www.efsa.europa.eu/en/topics/topic/food-additives. Accessed 15 Aug 2022. European Parlament, Council of the European Union. Regulation (EC) No 1334/2008 of the European Parliament and of the Council of 16 December 2008 on flavourings and certain food ingredients with flavouring properties for use in and on foods and amending Council Regulation (EEC) No 1601/91, Regulations (EC) No 2232/96 …

SIRPα antibody combined with oncolytic virus OH2 protects against tumours by activating innate immunity and reprogramming the tumour immune microenvironment | BMC Medicine

Cell line and oncolytic virus The CT26, MC38, 4T-1, and RAW264.7 cell lines were purchased from the National Infrastructure of Cell Line Resource (Beijing, China) and kept by our laboratory. The cells were cultured in a constant temperature incubator containing 5% CO2 at 37°C. OH2 was provided by Binhui Biopharmaceutical Co., Ltd. (Wuhan, China). The virus was an attenuated OH2 …

Lycium barbarum polysaccharide improves dopamine metabolism and symptoms in an MPTP-induced model of Parkinson’s disease | BMC Medicine

Jankovic J. Parkinson’s disease: clinical features and diagnosis. J Neurol Neurosur Ps. 2008;79:368–76. https://doi.org/10.1136/jnnp.2007.131045. Article  CAS  Google Scholar  Ali K, Morris HR. Parkinson’s disease: chameleons and mimics. Pract Neurol. 2015;15(1):14–25. https://doi.org/10.1136/practneurol-2014-000849. Read moreScientists ID pathway that triggers mice to scratch when they see others do the same – Washington University School of Medicine in St. LouisArticle  PubMed  Google Scholar  Gilberto …

Clinical translation of stem cell therapy for spinal cord injury still premature: results from a single-arm meta-analysis based on 62 clinical trials | BMC Medicine

James SL, Theadom A, Ellenbogen RG, Bannick MS, Montjoy-Venning W, Lucchesi LR, et al. Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019;18(1):56–87. Article  Google Scholar  Flack JA, Sharma KD, Xie JY. Delving into the recent advancements of spinal cord injury …